![]() This has resulted in improved tolerability Citation2 and a more favourable cardiovascular risk profile Citation3, Citation4. Over the past few decades, many advances have been achieved in COCs, including a reduction in the dose of the oestrogenic component ethinylestradiol (EE) and the introduction of more selective progestogens. Since their introduction 50 years ago, combined oral contraceptives (COCs) have become the most frequently used method of reversible contraception worldwide Citation1. NOMAC/E2 was associated with a greater increase in SHBG.Ĭonclusions The monophasic COC NOMAC/E2 had less influence on haemostasis, lipids and carbohydrate metabolism than the COC LNG/EE. A much smaller increase in CRP was observed with NOMAC/E2 than with LNG/EE. ![]() NOMAC/E2 induced negligible changes in glucose and insulin parameters, in contrast to LNG/EE. Lipids were essentially unchanged with NOMAC/E2, whereas with LNG/EE high-density lipoprotein cholesterol decreased and low-density lipoprotein cholesterol and triglycerides slightly increased. Over six cycles, NOMAC/E2 had less effect on most haemostatic indices than LNG/EE. Results All parameters were similar at baseline between the two groups. ![]() The primary outcome was the change from baseline to cycle 6 for all indices. Methods In a randomised, open-label study, 121 healthy women, 18–50 years of age, were randomly assigned to receive NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen ( n = 60) or LNG/EE (150 μg/30 μg) in a 21/7-day regimen ( n = 61) for six cycles. Objectives To compare the effects of a combined oral contraceptive (COC) containing nomegestrol acetate and 17β-oestradiol (NOMAC/E2) on haemostasis, lipids, carbohydrate metabolism, C-reactive protein (CRP) and sex hormone-binding globulin (SHBG) with those of a COC containing levonorgestrel and ethinylestradiol (LNG/EE). ![]()
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